Benefits Of Mangosteen Peel Extract
Until recently, it has been widely utilization of traditional medicinal plants by
the people of Indonesia to cope some of the disease.
The benefits of the use of the drug traditionally these have been widely perceived by the community.
This is also reflected with the increasing use of traditional medicine,
or increasing production the drug of the industry-the industry of traditional medicine.
Along with there slogan “back to nature”, and a prolonged economic crisis
resulting in the purchasing power of the society especially middle class people below, the use of traditional medicine to be alternative treatment of the modern medicine.
The utilization of medicinal plants include prevention, treatment and the maintenance of health. Many medicinal plants traditionally that has been marketed among other things as the prevention or treatment of a disease. Despite this, scientific evidence keberkhasiatan a variety of medicinal plants related, has not been reported.
One of the plants of Indonesia that can be used for such purposes is the fruit of the mangosteen (G. mangostana L.), especially the utilization of the skin of the fruit. Mangosteen is one of favorite fruit which is favored by the people of Indonesia. Skin the mangosteen fruit is discarded, it can be developed as a candidate drug. On this article will be presented about the the utilization of the skin of the mangosteen fruit (G. mangostana L.) in the effort of discovery a new drug.
MANGOSTEEN (Garcinia mangostana L.)
Mangosteen is one fruit favored by Indonesian society.
Mangosteen comes from a tropical forest the shade in Southeast Asia,
ie the forest wilds of Indonesia or Malaysia. From Southeast Asia,
this plant spread to the area of Central America and tropical regions other such as the Philippines, Papua New Guinea, Cambodia, Thailand, Srilanka, Madagascar, Honduras, Brazil and Northern Australia. Mangosteen is one of the fruits featured Indonesia, which has the export opportunities quite promising. From year to year the demand increases with mangosteen consumer demand for fruit got the nickname queen of fruits (Queen of Fruits). The export of mangosteen from Indonesia experience an increase in line with the needs of the fruit mangosteen the world especially Hongkong, Singapore, and the United kingdom. In 1999, the volume of exports of 4743493 kg with a value of exports of U.S.$ 3887816 and 2000 the volume of exports reached 7182098 kg with a value of exports of U.S.$ 5885038 (Prihatman, 2000; ICUC, 2003).
THE UTILIZATION OF THE SKIN OF THE FRUIT MANGOSTEEN
The skin of the mangosteen that is only disposed of course turned out to save a hope to be developed as a candidate drugs. The skin of the mangosteen fruit after investigation it turned out to contain several compounds with pharmacological activity for example anti-inflammatory, antihistamine, treatment of heart disease, antibacterial, antifungal even for the treatment or therapy of the disease HIV. Some of the compounds of the main content the skin of fruit mangosteen reported responsible for some activity pharmacology is a class of xanton. Compounds xanton has been identified, such as 1,3,6-trihydroxy-7-methoxy-2,8-bis(3- methyl-2-butenil)- 9H-xanten-9-on and 1,3,6,7- tetrahydroxy-2,8-bis(3-methyl-2-butenil)- 9H�xanten-9-on. Both are better known by the name of alpha mangostin and gamma-mangostin (Jinsart, 1992). Ho et al (2002) reported compounds xanton isolated from the skin of the fruit mangosteen, it also shows activity pharmacology, namely the suis butcher E. More, Jung et al (2006) successfully identified the content of xanton of extract soluble in dichloromethane, which is 2 xanton terprenilasi oxygenated and 12 xanton other. Two compounds xanton terprenilasi oxygenated is 8-hidroksikudraksanton G, and mangostingon [7-methoxy-2-(3-methyl-2- butenil)-8-(3-methyl-2-oxo-3-butenil)-1,3,6- trihidroksiksanton. While the twelfth xanton other is : kudraksanton G, 8- deoksigartanin, garsimangoson B, audible D, audible E, gartanin, 1-isomangostin, alpha�mangostin, gamma-mangostin, mangostinon, smeathxanthon A, and tovofillin A.
THE STUDY OF THE PHARMACOLOGY OF THE SKIN OF THE FRUIT MANGOSTEEN
The utilization of the skin of the mangosteen fruit actually already done since the first. The skin of the mangosteen fruit for traditional used on a variety of treatment in the country India, Myanmar, Sri lanka, and Thailand (Mahabusarakam et al., 1987).
The following will be presented discussion of pharmacological effects of the skin of the mangosteen fruit.
A. the Activity of antihistamines
B. Anti-Inflammatory
C. Anti-oxidants
D. Anticancer
E. Antimikroorganisme
F. other Activities
the people of Indonesia to cope some of the disease.
The benefits of the use of the drug traditionally these have been widely perceived by the community.
This is also reflected with the increasing use of traditional medicine,
or increasing production the drug of the industry-the industry of traditional medicine.
Along with there slogan “back to nature”, and a prolonged economic crisis
resulting in the purchasing power of the society especially middle class people below, the use of traditional medicine to be alternative treatment of the modern medicine.
The utilization of medicinal plants include prevention, treatment and the maintenance of health. Many medicinal plants traditionally that has been marketed among other things as the prevention or treatment of a disease. Despite this, scientific evidence keberkhasiatan a variety of medicinal plants related, has not been reported.
One of the plants of Indonesia that can be used for such purposes is the fruit of the mangosteen (G. mangostana L.), especially the utilization of the skin of the fruit. Mangosteen is one of favorite fruit which is favored by the people of Indonesia. Skin the mangosteen fruit is discarded, it can be developed as a candidate drug. On this article will be presented about the the utilization of the skin of the mangosteen fruit (G. mangostana L.) in the effort of discovery a new drug.
MANGOSTEEN (Garcinia mangostana L.)
Mangosteen is one fruit favored by Indonesian society.Mangosteen comes from a tropical forest the shade in Southeast Asia,
ie the forest wilds of Indonesia or Malaysia. From Southeast Asia,
this plant spread to the area of Central America and tropical regions other such as the Philippines, Papua New Guinea, Cambodia, Thailand, Srilanka, Madagascar, Honduras, Brazil and Northern Australia. Mangosteen is one of the fruits featured Indonesia, which has the export opportunities quite promising. From year to year the demand increases with mangosteen consumer demand for fruit got the nickname queen of fruits (Queen of Fruits). The export of mangosteen from Indonesia experience an increase in line with the needs of the fruit mangosteen the world especially Hongkong, Singapore, and the United kingdom. In 1999, the volume of exports of 4743493 kg with a value of exports of U.S.$ 3887816 and 2000 the volume of exports reached 7182098 kg with a value of exports of U.S.$ 5885038 (Prihatman, 2000; ICUC, 2003).
THE UTILIZATION OF THE SKIN OF THE FRUIT MANGOSTEEN
The skin of the mangosteen that is only disposed of course turned out to save a hope to be developed as a candidate drugs. The skin of the mangosteen fruit after investigation it turned out to contain several compounds with pharmacological activity for example anti-inflammatory, antihistamine, treatment of heart disease, antibacterial, antifungal even for the treatment or therapy of the disease HIV. Some of the compounds of the main content the skin of fruit mangosteen reported responsible for some activity pharmacology is a class of xanton. Compounds xanton has been identified, such as 1,3,6-trihydroxy-7-methoxy-2,8-bis(3- methyl-2-butenil)- 9H-xanten-9-on and 1,3,6,7- tetrahydroxy-2,8-bis(3-methyl-2-butenil)- 9H�xanten-9-on. Both are better known by the name of alpha mangostin and gamma-mangostin (Jinsart, 1992). Ho et al (2002) reported compounds xanton isolated from the skin of the fruit mangosteen, it also shows activity pharmacology, namely the suis butcher E. More, Jung et al (2006) successfully identified the content of xanton of extract soluble in dichloromethane, which is 2 xanton terprenilasi oxygenated and 12 xanton other. Two compounds xanton terprenilasi oxygenated is 8-hidroksikudraksanton G, and mangostingon [7-methoxy-2-(3-methyl-2- butenil)-8-(3-methyl-2-oxo-3-butenil)-1,3,6- trihidroksiksanton. While the twelfth xanton other is : kudraksanton G, 8- deoksigartanin, garsimangoson B, audible D, audible E, gartanin, 1-isomangostin, alpha�mangostin, gamma-mangostin, mangostinon, smeathxanthon A, and tovofillin A.
THE STUDY OF THE PHARMACOLOGY OF THE SKIN OF THE FRUIT MANGOSTEEN
The utilization of the skin of the mangosteen fruit actually already done since the first. The skin of the mangosteen fruit for traditional used on a variety of treatment in the country India, Myanmar, Sri lanka, and Thailand (Mahabusarakam et al., 1987).
The following will be presented discussion of pharmacological effects of the skin of the mangosteen fruit.
A. the Activity of antihistamines
B. Anti-Inflammatory
C. Anti-oxidants
D. Anticancer
E. Antimikroorganisme
F. other Activities